Endocrine Abstracts

Introduction: Immune checkpoint inhibitors (ICI) show promising efficacy in the treatment of a wide range of advanced cancers, butlong-term response is currently limited to a subset of patients. Sarcopenia is a condition characterized by loss of skeletal muscle mass and decreased muscle function which occurs in approximately 50% of advanced cancer patients,related to malnutrition, inflammation, and treatments.Objective: The aim of this prospective o...

Background: Bilateral testicular germ cell tumors (B-TCGT) are reported as rare findings (incidence 1-8%) and can be distinguish in synchronous (sB-TCGT) (recurrence within 3 months) and metachronous (mB-TCGT) (recurrence after 3 months). Risk factors of relapse are still underexplored. The aim of our study was to identify clinical, biochemical and radiological risk factors for the onset of a second tumor in a wide cohort of TGCT patients. Materials and ...

Introduction: Immune-Checkpoint Inhibitors (ICI) are frequently associated with thyroid-related adverse events (AE). Several studies analyzed thyroid disfunctions during ICI therapy, but many aspects remain to be characterized, especially for the most recent anti-PD-1 drugs. The aim of this study is to determine incidence and characteristics of PD-1 inhibitors associated thyroid dysfunction.Methods: We retrospectively analyzed data of patients with advan...